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Herpes Simplex Virus Type 1 and 2, IHC with Interpretation
Test Code16720
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Do not freeze.
Do not freeze.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemical Stain (IHC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri a.m.; Report available: 2 days
Reference Range
See Laboratory report
Clinical Significance
For the detection of HSV infected tissue. Two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 or oral) and HSV-2 (type 2 or genital), can establish lifelong latent infections with sensory ganglia. Periodically, the virus reactivates and can cause recurrent cold sores, encephalitis and eye and genital infections. HSV-1 usually establishes latency in the trigeminal ganglion, a collection of nerve cells near the ear. From there, it tends to recur on the lower lip or face. HSV-2 usually resides in the sacral ganglion at the base of the spine. From there, it reiterates in the genital area.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153