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Prosigna® Breast Cancer Prognostic Gene Signature Assay
Test Code92125
CPT Codes
81520
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted in an IHC transport kit
Other Acceptable Specimens
6 unstained 10-micron slides in tissue transport kit
Instructions
Surgical pathology report required.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed excised tissue. Protect from excessive heat. Transport tissue block or 6 unstained 10-micron slides. (minimum: 3 slides). Transport block(s) and/or slide(s) in a tissue transport kit (recommended but not required).
Formalin fix (10 percent neutral buffered formalin) and paraffin embed excised tissue. Protect from excessive heat. Transport tissue block or 6 unstained 10-micron slides. (minimum: 3 slides). Transport block(s) and/or slide(s) in a tissue transport kit (recommended but not required).
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens fixed/processed in alternative fixatives • (alcohol, Prefer) • Decalcified specimens • Needle core biopsy • <10% tumor
Methodology
Hybridization/gene expression
Setup Schedule
Set up: Varies; Report available: 13-15 days
Reference Range
See Laboratory Report
Clinical Significance
Assess the risk of distant recurrence in post-menopausal women with early stage (stage I or stage II), hormone receptor-positive (ER+ and/or PR+) breast cancer. Useful in both node-negative and node-positive (1-3 nodes) disease.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |