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Unstable Hemoglobin
Test Code29385
CPT Codes
83068
Preferred Specimen
8 mL random whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: Unacceptable
Refrigerated: 7 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Alcohol Precipitation
Setup Schedule
Set up: Daily; Report available: 1-5 days
Reference Range
None detected
Clinical Significance
Unstable hemoglobins result from mutations around the heme pocket as well as contact points between the individual globin subunits resulting in hemolytic anemia. Hemoglobins carrying these structural modifications may denature and precipitate when exposed to alcohol, such as isopropanol.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153