IgG4, IHC with Interpretation

Test Code

91315

CPT Codes
88342

Preferred Specimen

1 formalin-fixed, paraffin-embedded tissue block

Minimum Volume

1 Block

Other Acceptable Specimens

3 unstained, (+) charged slides, submitted in IHC Specimen Transport Kit

Instructions

Please include surgical pathology report.

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received frozen

Methodology
Immunohistochemistry (IHC)

Setup Schedule

Setup: Mon-Fri a.m.; Report available: 3 days

Reference Range

See Laboratory Report

Clinical Significance

IgG4-related sclerosing disease is a clinicopathologically-defined immune disorder that can present in lymph node or other tissues. An increased number of IgG4+ plasma cells detected by this antibody can help establish the diagnosis, with cases showing histologic features of cutaneous pseudolymphomas and/or intra-germinal center and interfollicular plasmacytosis. Although the presence of increased numbers of IgG4+ plasma cells is not specific for this disease it can help differentiate it from inflammatory myofibroblastic tumor which typically shows absent or rare IgG4+ plasma cells.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.