Thrombotic Marker Panel [11345X]

Test Code

CPT Codes
85362, 85379, 83520 (x2)

D-Dimer, Quantitative
Fibrin Monomer
Prothrombin Fragment 1.2
Thrombin- Antithrombin (TAT) Complex

Preferred Specimen
2 mL platelet-poor plasma collected in each three separate 3.2% sodium citrate (light blue-top) tubes

Minimum Volume
1 mL (x3)

Platelet Poor Plasma: Centrifuge light blue-top tube 15 minutes at approx. 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s).
Freeze immediately and ship on dry ice.

Transport Temperature

Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis

Enzyme Immunoassay (EIA) • Enzyme Linked Immunosorbent Assay (ELISA) • Hemagglutination (HA) • Immunoturbidimetric

Setup Schedule
Set up and Report available: See individual assays

Reference Range
See individual tests

Clinical Significance
When intravascular thrombosis is suspected in the absence of overt clinical symptoms, elevation in D-dimer, fibrin monomer, prothrombin fragment 1.2, or thrombin-antithrombin complex may be the only indicator of intravascular clot formation and generation of activated factor X. Marked elevation in only 1 or 2 of these markers should lead to further investigation of the site of the thrombosis (eg, early dissecting aortic aneurysm, anomalous arterial/venous fistula).

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.