P57, IHC with Interpretation

Test Code

90177

CPT Codes
88342

Preferred Specimen

1 formalin fixed paraffin block

Minimum Volume

1 block

Other Acceptable Specimens

3 Slides Unstained, positively charged slides IHC Specimen Transport Kit

Instructions

Please include surgical pathology report.

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Do Not Freeze

Methodology
Immunohistochemistry

Setup Schedule

Set up: Mon-Fri Morning; Report available: 3 days

Reference Range

Interpretive report

Clinical Significance

Immuostaining for p57, a nuclear cell cycle regulator, can help discriminate between complete hydatidiform mole, which lacks p57 expression in cytotrophoblasts, from partial hydatidiform mole and hydropic abortion where p57 expression is intact. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and can serve as an internal control.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.