Epstein-Barr Virus, ISH without Interpretation [16689X]

Test Code

16689

CPT Codes
88365

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens

3 unstained, positively charged slides

Instructions

Please include surgical pathology report.

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Methodology
In Situ Hybridization (ISH)

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 2 days

Clinical Significance

The presence of Epstein-Barr virus (EBV) in tumors or reactive tissues can be detected by expression of the EBV-associated small RNAs (EBERs) using in situ hybridization. EBER expression is seen in all EBV-associated malignancies including classical Hodgkin lymphoma (most commonly mixed cellularity type), nasopharyngeal carcinoma, post-transplant B-cell lymphoproliferative disorders, a subset of diffuse large B-cell lymphomas, extranodal NK/T-cell lymphoma, nasal type, and some childhood T-cell lymphoproliferative disorders.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.