A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Free Progesterone Profile
Test Code15072
CPT Codes
84144 (x2)<br>This test is not available for New York patient testing
Preferred Specimen
3 mL frozen serum
Patient Preparation
Patient should not be on any Corticosteroid, ACTH, Estrogen, or Gonadotropin medication, if possible, for at least 48 hours prior to collection of specimen.
Minimum Volume
2 mL
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube
Instructions
3 mL serum or EDTA plasma should be collected and separated and frozen as soon as possible.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 90 days
Refrigerated: 7 days
Frozen: 90 days
Methodology
Radioimmunoassay following ultrafiltration of specimens
Setup Schedule
Set up: Mon-Fri; Report available: 12 days
Reference Range
Free Progesterone | |
Male: | 5-20 ng/dl |
Female: | Up tp 50 ng/dl |
Free Progesterone (As a % of Total Progesterone) | |
Male: | 11-57 % |
Female: | 5-64 % |
Progesterone, Total | |
Male: | 50-50 ng/dl |
Female: | |
Follicular: | 10-100 ng/dl |
Luteal: | 200-1800 ng/dl |
Clinical Significance
Progesterone is a Progestin produced primarily from enzymatic metabolism of Pregnenolone. It is enzymatically converted to 17-Hydroxy Progesterone and 11-Deoxycorticosterone. It is secreted by both the gonads and the adrenal glands. It is mostly bound to Cortisol Binding Globulin and Albumin, but a small percentage is present in the "Free" form. This "Free" Progesterone is the bioactive moiety. It is excreted into the urine primarily as "Free" unconjugated Progesterone and as Pregnanediol. Progesterone is responsible for cellular changes in the cervix, vagina, and uterus. Levels are lowest in the follicular phase and increase rapidly following the luteal surge. Increased Progesterone inhibits ovulation. "Free" Progesterone increases greatly during pregnancy reaching about 20% of the total Progesterone concentration at delivery. Measurement of Progesterone can be useful to monitor fertility, corpus luteum function, endometrial development, and be helpful in in-vitro fertilization patients.
Performing Laboratory
Inter Science Institute
944 W Hyde Park Blvd
Inglewood, CA 90302