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Hu Antibody Screen with Reflex to Titer and Western Blot, CSF
Test Code37710
CPT Codes
86255
Includes
If Hu Antibody Screen, IFA, CSF is positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Hu Antibody, WB, CSF is positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Preferred Specimen
3 mL CSF collected in a sterile, plastic leak-proof container
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1.5 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Methodology
Immunofluorescence Assay (IFA) • Western Blot (WB)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Wed, Fri; Report available: 4 days
Reference Range
Hu Ab Screen, IFA, CSF | Negative |
Hu Ab, WB, CSF | Negative |
Hu Ab Titer, CSF | No Hu Antibodies detected in undiluted CSF samples |
Clinical Significance
Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |