Prostate Triple Stain (P504S, HMW, Keratins, P63), IHC without Interpretation

Test Code

91479

CPT Codes
88342-TC, 88344-TC

Includes

(P504S, HMW Keratins, P63)

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens

Minimum: 5 unstained, positively charged slides

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Methodology
Immunohistochemistry (IHC)

Setup Schedule

Set up: Mon-Fri a.m.; Report available: Next day

Reference Range

See Laboratory Report

Clinical Significance

Pathologic evaluation of prostate cancer can be challenging, especially when there is a small focus of cancer. Because benign prostate glands contain basal cells, while cancerous glands do not, differential staining of basal cells in the prostate may be useful for diagnosis. This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial tissue. This combination may help differentiate prostate cancer from precancerous lesions such as prostatic intraepithelial neoplasia (PIN), especially when tissue is limited.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.