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TIA-1, IHC with Interpretation
Test Code90186
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted in an IHC specimen transport kit
Other Acceptable Specimens
3 unstained, (+) positively charged slides
Instructions
Please include surgical pathology report.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
TIA-1, a cytoplasmic/granule marker that is associated with cytotoxic lymphocytes, is positive in T-cell and NK large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T or NK phenotype. Most anaplastic large cell lymphomas will also show variable reactivity.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
