TIA-1, IHC with Interpretation

Test Code

CPT Codes

Preferred Specimen
Minimum: 1 formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens
3 unstained slides, positively charged, submitted in an IHC specimen transport kit

Please include surgical pathology report.

Transport Container
IHC specimen transport kit

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Setup Schedule
Set up: Mon-Fri; a.m.; Report available: 3 days

Reference Range
See Laboratory Report

Clinical Significance
TIA-1, a cytoplasmic/granule marker that is associated with cytotoxic lymphocytes, is positive in T-cell and NK large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T or NK phenotype. Most anaplastic large cell lymphomas will also show variable reactivity.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.