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Anti Th/To Ab (RDL)
Test Code91290
CPT Codes
83516
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube
Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 60 days
Refrigerated: 14 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Bacterial contamination • Lipemic specimen • Icteric specimen • Non-serum specimen types
Methodology
RIPA gel radiography
Setup Schedule
Set up: Varies; Report available: 11-15 days
Reference Range
Negative
Clinical Significance
The Th/To is a component of the 7-2/MRP RNP. Most of the 7-2/MRP RNP is found in the GC region of the nucleolus and <1% of this snoRNP appears located in mitochondria. The Th/To antibodies are present in 10-19% of patients with limited SSc, in 11% of patients with diffuse cutaneous SSc, and in 3% of patients with primary Raynaud's disease. Anti-Th/To antibody has been shown to be highly specific for patients with SSc. The anti-Th/To antibody detection is an in-house bioassay performed at RDL for a qualitative determination of Th/To antibody in serum by immunoprecipitation. The Th/To antibody assay will be labeled as an Analytic Specific Reagent (ASR).
Performing Laboratory
Esoterix Inc.
4301 Lost Hills Road
Calabasas, CA 91301-5358
