TCL1, IHC with Interpretation

Test Code

CPT Codes

Preferred Specimen
Formalin-fixed paraffin-embedded tissue block submitted in an IHC Specimen Transport kit

Minimum Volume
3 slides

Other Acceptable Specimens
5 unstained, positively charged slides

Please include surgical pathology report.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Setup Schedule
Set up: Mon-Sat; Report available: 2-4 days

Reference Range
Interpretive report

Clinical Significance
The T-cell leukemia/lymphoma protein 1 (TCL1) is an AKT kinase regulator that is expressed in B cells up to the germinal stage and in plasmacytoid dendritic cells. TCL1 is strongly expressed, due to the chromosomal rearrangements, t(14;14)(q11;q32) and inv(14)(q11;q32), in 70% of cases of T-cell prolymphocytic leukemia (T-PLL) but is negative in all other mature T-cell lymphomas and leukemias. TCL1 is also expressed in nearly all cases of blastic plasmacytoid dendritic cell neoplasms, and can be used to distinguish this tumor from monocytic neoplasms. High TCL1 levels correlate with the pre-germinal center genetic subtype and are a strong adverse prognostic factor in B-cell chronic lymphocytic leukemia.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.