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Alpha-1-Antitrypsin (AAT) Quantitation and Mutation Analysis
Test Code17307
CPT Codes
82103, 81332
Preferred Specimen
1 mL serum and 5 mL whole blood collected in EDTA (lavender-top) tube
Minimum Volume
0.5 mL serum • 2 mL whole blood
Other Acceptable Specimens
Serum and Whole blood collected in sodium heparin (green-top) tube, or ACD solution A or B (yellow-top) tube
Instructions
Serum and whole blood is required
Transport Temperature
Room temperature
Specimen Stability
Serum
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 90 days
Whole blood
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 90 days
Whole blood
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Methodology
Fluorescent Restriction Fragment Length Polymorphism • Immunoturbidimetric Assay
Setup Schedule
Set up: Varies with assay; Report available: 3-6 days
Limitations
Rare alleles (other than S and Z types) are not tested for by this assay.
Reference Range
| A-1 Antitrypsin Mutation | See Laboratory Report |
| Alpha-1-Antitrypsin | Adults: 83-199 mg/dL |
Clinical Significance
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1-Antitrypsin Deficiency. Am J Respir Crit Care Med. 2003, vol. 168, 818-900.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
