A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
17-Hydroxy Progesterone, Urine
Test Code39488
CPT Codes
83498<br /> This test is not available for New York patient testing.
Preferred Specimen
10 mL aliquot of a 24 hour urine submitted in a plastic, leak-proof container
Minimum Volume
5 mL
Other Acceptable Specimens
10 mL random urine
Instructions
Patient should not be on any Corticosteroid, ACTH, Estrogen, or Gonadotropin medications, if possible, for at least 48 hours prior to collection of specimen. No special preservatives are required.
Store specimens refrigerated during collection. Specimens should be frozen prior to shipping.
Note: Ship specimens frozen on dry ice. Provide the total volume.
Store specimens refrigerated during collection. Specimens should be frozen prior to shipping.
Note: Ship specimens frozen on dry ice. Provide the total volume.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 1 hour
Refrigerated: 4 days
Frozen: 6 months
Refrigerated: 4 days
Frozen: 6 months
Methodology
Radioimmunoassay (RIA) following Extraction
Setup Schedule
Set up: Test batched 1-5 times per week; Report available: 10 days
Reference Range
Pediatric
Adult
Newborns and Infants | 3 Days-1 Year | up to 50 | ng/24 hrs | |
Children | 1-8 years | up to 300 | ng/24 hrs |
Adult
Male | up to 2.0 | ug/24 hrs |
Female | up to 4.5 | ug/24 hrs |
Clinical Significance
17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with polycystic ovarian disease and congenital adrenal hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21 alpha-hydroxylase deficient congenital adrenal hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.
Performing Laboratory
Inter Science Institute
944 West Hyde Park Blvd
Inglewood, CA 90302-3308