17-Hydroxy Progesterone, Random Urine

Test Code

39488

CPT Codes
83498<br>This test is not available for New York patient testing.

Preferred Specimen

10 mL random urine collected in a plastic, leak-proof container - no preservative

Patient Preparation
Patient should not be on any Corticosteroid, ACTH, Estrogen, or Gonadotropin medications, if possible, for at least 48 hours prior to collection of specimen.

Minimum Volume

5 mL

Instructions

10 mL of a random urine collection should be submitted for analysis. No special preservatives are required. Store specimen refrigerated during collection. Specimens should be frozen prior to shipping. Minimum specimen size is 5 mL.

Transport Temperature

Frozen

Specimen Stability

Room temperature: 1 hour
Refrigerated: 4 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly icteric • Gross hemolysis • Grossly lipemic

Methodology
Radioimmunoassay (RIA) following Extraction

Setup Schedule

Set up: Varies; Report available: 8 business days

Reference Range

Pediatric

Newborns and Infants		3 Days-1 Year	up to 50	ng/24 hrs
Children		1-8 years	up to 300	ng/24 hrs

Adult

Male	up to 2.0	ug/24 hrs
Female	up to 4.5	ug/24 hrs

Clinical Significance

17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with polycystic ovarian disease and congenital adrenal hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21 alpha-hydroxylase deficient congenital adrenal hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.

Performing Laboratory
Inter Science Institute
944 West Hyde Park Blvd
Inglewood, CA 90302-3308

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.