Rufinamide

Test Code

16296

CPT Codes
80210

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Patient Preparation
A trough specimen is preferred

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube

Instructions

Collect sample within 1 hour prior to next dose

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 30 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tube (SST®)

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Fri; Report available: 2-6 days

Report Available

2-6 days

Reference Range

Maintenance therapy with 45 mg/kg (approximately 1600 mg) daily Rufinamide resulted in plasma concentrations ranging from 5.0-55.0 mcg/mL.

Clinical Significance

Rufinamide is an antiepileptic indicated for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children and adults. As multiple antiepileptics may be administered, it may be important to (1) optimize therapy, (2) monitor compliance, and (3) avoid toxicity.

Performing Laboratory
Quest Diagnostics Nichols Institute
Valencia 27027 Tourney Road
Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.