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PD-1, IHC with Interpretation
Test Code91321
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable
Refrigerated: Indefinite
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri a.m.; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
The programmed death-1 (PD1) protein is expressed by follicular helper T-cells and is useful in the diagnosis of T-cell lymphomas and in highlighting L&H cells in Hodgkin lymphoma. Anti-PD-1 antibody has been used as anti-tumor immunotherapy agents. This effect is possibly due to the targeting of PD1 expressing tumor-infiltrating lymphocytes which can be enumerated by this antibody.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |