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Hepatitis B Core Antibody (Total) with Reflex to IgM
Test Code37676
CPT Codes
86704
Includes
If Hepatitis B Core Antibody Total is reactive, then Hepatitis B Core IgM Antibody will be performed at an additional charge (CPT code(s): 86705).
Preferred Specimen
1 mL serum
Minimum Volume
0.8 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: Next day
Limitations
Results obtained from immunosuppressed patients should be interpreted with caution. Patients receiving mouse antibody therapy may produce false-negative results. False-positives may be detected shortly after immunization to influenza and with patients with hypergammaglobulinemia, positive rheumatoid factor, and connective tissue disorders.
Reference Range
Hepatitis B Core Antibody, Total | Non-Reactive |
Clinical Significance
This assay detects presence of both IgG and IgM antibodies to the hepatitis B core (anti-HBc) antigen. If positive, it reflexes to further detect only the presence of IgM anti-HBc. When both the total anti-HBc and IgM anti-HBc are positive, it is indicative of acute HBV infection. A positive total anti-HBc with negative IgM anti-HBc is indicative of either acute or past Hepatitis B infection. Total anti-HBc may be the only HBV marker detected in past infection. Anti-HBc antibodies, both total and IgM, are absent from HBV vaccinated people.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153