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SurePath™ Pap and HPV mRNA E6/E7 Reflex Genotypes 16, 18/45
Test Code16306
CPT Codes
87624, 88142<br>This test is not available for California patient testing.
Includes
SurePath™ Pap
HPV mRNA E6/E7 with Reflex to HPV Genotypes 16, 18/45
Pap results requiring physician interpretation will be performed at an additional charge (CPT Code(s): 88141; HCPCS: G0124).
If the Pap is normal and the HPV mRNA E6/E7 is detected, then HPV Genotypes 16, 18/45 will be performed at an additional charge (CPT Code(s): 87625).
HPV mRNA E6/E7 with Reflex to HPV Genotypes 16, 18/45
Pap results requiring physician interpretation will be performed at an additional charge (CPT Code(s): 88141; HCPCS: G0124).
If the Pap is normal and the HPV mRNA E6/E7 is detected, then HPV Genotypes 16, 18/45 will be performed at an additional charge (CPT Code(s): 87625).
Preferred Specimen
Pap sample collected in 1 SurePath™ pap vial
Minimum Volume
1 SurePath pap vial
Instructions
For instructions refer to
//www.questdiagnostics.com/dms/Documents/Other/Specimen_Collection_and_Transport_Guide_2019.pdf
//www.questdiagnostics.com/dms/Documents/Other/Specimen_Collection_and_Transport_Guide_2019.pdf
Transport Container
1 SurePath pap vial
Transport Temperature
Room temperature
Specimen Stability
SurePath Pap
Room temperature: 28 days
Refrigerated: 6 months
Frozen: Unacceptable
SurePath HPV
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
SurePath Preservative in Aptima Transfer Tube
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
Refer to local service area for specimen retention
Room temperature: 28 days
Refrigerated: 6 months
Frozen: Unacceptable
SurePath HPV
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
SurePath Preservative in Aptima Transfer Tube
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
Refer to local service area for specimen retention
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
SurePath™ vials without the head of the collection device(s) in the fluid • Swabs • SurePath vials received frozen • Cervical swabs in Digene® HC cervical sampler • Digene vials
Methodology
Liquid Based-density Gradient Sedimentation • Transcription-Mediated Amplification (TMA)
Setup Schedule
Set up: Mon-Sat; Report available: 5 days
Reference Range
See Laboratory Report
Clinical Significance
The combination of tests will assist in triaging patients over age 30 who have a normal pap and a positive HPV. This combination of results automatically adds a molecular genotyping assay that detects HPV 16 and 18. The genotype results assist in determining which women should be referred for colposcopy.
This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).
This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153