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Aldosterone/Cortisol Ratio, Adrenal Vein Sampling, 1 Site
Test Code19573
CPT Codes
82088, 82533
Includes
Aldosterone
Cortisol, Total
Aldosterone/Cortisol Ratio
Cortisol, Total
Aldosterone/Cortisol Ratio
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Instructions
Ship frozen, do not thaw.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate to gross hemolysis • Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: 2-6 days
Reference Range
See Laboratory Report
Clinical Significance
Measurements of aldosterone/cortisol ratios in specimens from adrenal venous blood, obtained by an experienced radiologist, is the "gold standard" test to distinguish between an adenoma or unilateral hyperplasia and bilateral hyperplasia. Unilateral disease is associated with a marked (usually greater than four-fold) increase in the aldosterone/cortisol ratio on the side of the tumor, whereas there is little difference between the two sides in patients with bilateral hyperplasia. AVS (adrenal vein sampling) with aldosterone/cortisol measurement is indicated if imaging studies fail to unequivocally identify an adenoma or if the identified adenoma is <1 cm in size.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
