Prometheus® Celiac PLUS

Test Code

18027

CPT Codes
81382 (x2), 82784, 86231, 86258 (x2), 86364

Includes

Both Celiac Genetics (HLA DQ2/DQ8) and Celiac Serology will be performed.

Preferred Specimen

2 mL serum
--and--
2 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

1 mL

Instructions

Both serum and whole blood specimens are required for this test.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 30 days
Frozen: Unacceptable

Methodology
Chemiluminescent Immunoassay • Indirect Immunofluorescence Assay • Nephelometry • HLA-DQA1 • HLA-DQB1

Setup Schedule

Set up: Mon-Fri; Report available: 4 days

Reference Range

See Laboratory Report

Clinical Significance

Most celiac patients carry either the DQ2 (about 9 5% of celiacs) or the DQ8 haplotype (about 5% of celiacs). There are two DQ2 haplotypes, but only one DQ8 haplotype-specific combination that may confer different risks for the development of celiac disease, as shown above(3).
1) Pietzak M, et al., Stratifying Risk for Celiac Disease in a Large At-Risk United States Population by Using HLA Alleles. Clin Gastroenterol Hepatol. 2009; 7:966 - 971.
2) Fasano A, Berti I, et al., Prevalence of celiac disease in at-risk and not at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003; 163: 286-292.
3) Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM, Pathomechanisms in celiac disease. Best Pract Res Clin Gastroenterol. 2005; 19: 373-387.

Performing Laboratory
Prometheus®
Therapeutics and Diagnostics
9410 Carroll Park Drive
San Diego, CA 92121

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.