Posaconazole

Test Code

94010

CPT Codes
80187<br><strong>This test is not available for New York patient testing.</strong>

Preferred Specimen

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

1 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tubes (SST) • Other body fluids

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Thurs, Sat.; Report available: 1-4 days

Reference Range

after 7 days of treatment

Target for prophylaxis purpose	trough level >0.7 mcg/mL
Target for salvage treatment	trough level >1.25 mcg/mL

Clinical Significance

The antifungal drug posaconazole is indicated for prophylaxis of invasive aspergillus and candida infections in severely immunocompromised patients. It may also be used in the treatment of oropharyngeal candidiasis refractory to itraconazole and fluconazole. The chronic nature of fungal infections demands constant monitoring of posaconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.

Performing Laboratory
Quest Diagnostics Lewisville
2501 South State Highway 121
Suite 1100
Lewisville, TX 75067-8188

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.