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Amino Acid Analysis, LC/MS, CSF
Test Code29881
CPT Codes
82139
Includes
Alanine, Alpha-Amino Adipic Acid, Alpha-Amino Butyric Acid, Arginine, Asparagine, Aspartic Acid, Beta-Alanine, Beta-Amino Isobutyric Acid, Citrulline, Gamma-Amino Butyric Acid, Glutamic Acid, Glutamine, Glycine, Histidine, Homocystine, Hydroxyproline, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine
Preferred Specimen
1 mL CSF submitted in a sterile plastic leak-proof CSF vial
Minimum Volume
0.25 mL
Instructions
Patient age is required for correct reference range. Freeze CSF below -20°C.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: 5 days
Reference Range
See Laboratory Report
Clinical Significance
Amino acid analysis is necessary for the diagnosis of a variety of inborn errors of metabolism. These include, but are not limited to, Phenylketonuria, Tyrosinemia, Citrullinemia, Non-Ketotic Hyperglycinemia, Maple Syrup Urine Disease, and Homocystinuria. The assay is also key for the continued monitoring of treatment plans for these disorders and useful for assessing nutritional status of patients. Our methodology is highly accurate at very low levels as well as at elevated levels.
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130