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HIV-1 Resistance and Coreceptor Tropism, Proviral DNA
Test Code94810
CPT Codes
87900, 87901, 87906 (x2)
Preferred Specimen
3 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1.2 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Methodology
Polymerase Chain Reaction (PCR) • Next Generation (ultra-deep) Sequencing
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics Infectious Disease. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Sat; Report available: 5-6 days
Reference Range
See Laboratory Report
Clinical Significance
This panel will assist clinicians to evaluate virologically suppressed patients for antiretroviral regimen modification when there is insufficient historical viral RNA resistance and viral tropism information. This test utilizes PCR and next generation (ultra-deep) sequencing of proviral DNA to detect drug resistance mutations in the HIV-1 protease, reverse transcriptase and integrase genes. As the CCR5 antagonist maraviroc may also be considered as a component of a new regimen, this panel includes the requisite tropism test performed on proviral DNA.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |