A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Hydroxyproline, Plasma
Test Code37558
CPT Codes
83500
Preferred Specimen
2 mL plasma collected in a sodium heparin (green-top) tube
Patient Preparation
Collect plasma specimens after an overnight fast (or at least 4 hours after a meal).
Non-fasting samples are acceptable for pediatric patients.
Minimum Volume
0.25 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, or lithium heparin (green-top) tube
Instructions
Plasma should be separated from cells as soon as possible after collection. Freeze plasma below -20° C.
Include date of collection and age of patient. Age must be provided for age related reference ranges to print on the final report.
Include date of collection and age of patient. Age must be provided for age related reference ranges to print on the final report.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Received room temperature
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Thurs, Fri; Report available: 6-10 days
Reference Range
≤30 days | 13-72 umol/L |
31 days-23 months | 7-63 umol/L |
2 years-17 years | 6-32 umol/L |
≥18 years | 4-27 umol/L |
Clinical Significance
Hydroxyproline is necessary for the construction of collagen. Defects in collagen synthesis lead to easy bruising, internal bleeding, breakdown of connective tissue of the ligaments and tendons, and increased risk to blood vessel damage. Increased loss of hydroxyproline in the urine is generally associated with breakdown of connective tissue, due to disease processes and may also be a manifestation of vitamin C deficiency.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |