Penta Screen

Test Code
15934


CPT Codes
81512<br /> This code is for non-New York clients only. For New York patient testing, use code 16970.

Includes

AFP, unconjugated Estriol, hCG, Dimeric Inhibin A, ITA (hyperglycosylated hCG) and Maternal Risk Interpretation



Preferred Specimen
4 mL serum


Minimum Volume
1.5 mL


Instructions

For manual orders use "Maternal Serum Screen Requisition".

The Penta Screen test in pregnant women should be performed between 14.0 and 22.9 weeks gestational age, although the optimal period is 15.0-16.9 weeks. This time frame allows sufficient opportunity for further diagnostic studies if the initial Penta Screen test results are abnormal. Specimens submitted before 14.0 weeks or after 22.9 weeks gestation cannot be properly evaluated for open neural tube defects, Down syndrome or Trisomy 18.

The "Maternal Serum Screen Requisition" designed to obtain patient data and the patient's informed consent must be utilized when ordering the Penta Screen test. Because the Penta Screen test results are influenced by certain patient characteristics, the following data must be provided with the specimen in order to permit accurate interpretation of results: date of collection, patient's (maternal) date of birth, patient's estimated date of delivery, patient's weight, patient's race, patient's diabetic status (is patient insulin-dependent prior to pregnancy), number of fetuses, and whether this is a repeat sample.



Transport Container
Plastic screw-cap vial


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia


Methodology
Immunoassay (IA)

Setup Schedule
Set up: Mon-Sat; Report available: 3-5 days


Limitations
Penta Screen results consistent with an increased risk of trisomy should be confirmed with amniotic fluid specimen. Results consistent with increased risk of NTD may be followed-up with appropriate diagnostic testing as detailed in the report. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening.


Reference Range
See Laboratory Report


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.