A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Hepatitis Panel, Acute with Reflex to Confirmation
Test CodeCPT Codes
80074
Includes
Hepatitis B Surface Antigen with Reflex to Confirmation
Hepatitis B Core Antibody (IgM)
Hepatitis C Antibody with Reflex to HCV, RNA, Quantitative, Real-Time PCR
Hepatitis B Surface Antigen: Positive samples will be confirmed based on the manufacturer's FDA approved recommendations at an additional charge (CPT code(s): 87341).
If Hepatitis C Antibody is reactive or borderline, then Hepatitis C Viral RNA, Quantitative, Real-Time PCR will be performed at an additional charge (CPT code(s): 87522).
Preferred Specimen
Minimum Volume
Instructions
Transport Container
Transport Temperature
Specimen Stability
Refrigerated: 14 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Immunoassay (IA)
Setup Schedule
Limitations
Reference Range
Clinical Significance
This panel may be helpful in the diagnosis of acute or recent infection with hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the 3 most common pathogens of viral hepatitis in the United States [1].
Acute symptoms and signs are similar among HAV, HBV, and HCV infection and may include fever, fatigue, loss of appetite, nausea, abdominal discomfort, dark urine, pale stools, and jaundice [1-4]. This panel may help establish diagnosis of these 3 viral hepatitis infections in symptomatic patients.
This panel includes 4 tests with reflexes: HAV IgM antibody, hepatitis B surface antigen (HBsAg) with reflex to confirmation, hepatitis B core IgM antibody (HBcAb IgM), and HCV antibody with reflex to HCV RNA quantitative real-time PCR.
The section below outlines the roles of the analytes assessed with this panel.
HAV IgM: Presence indicates current or recent infection or recent vaccination. A negative result indicates absence of acute infection [2].
HBsAg with reflex confirmation: Presence indicates that a person has a current HBV infection and is infectious [3].
HBcAb IgM: Presence indicates HBV infection within the preceding 4 to 6 months (ie, acute/recent infection) [3].
HCV antibody with reflex to HCV RNA: Presence (with detectable HCV RNA) indicates current infection. A positive result with a "not detected" HCV RNA reflex result may indicate a resolved infection or a biological false-positive antibody screening test [4].
The results of the test in the panel should be interpreted in the context of pertinent clinical history and physical examination findings.
References
1. Viral Hepatitis Surveillance - United States, 2019. Centers for Disease Control and Prevention. Accessed January 16, 2021. https://www.cdc.gov/hepatitis/statistics/2019surveillance/pdfs/2019HepSurveillanceRpt.pdf
2. Nelson NP, et al. MMWR Recomm Rep. 2020;69(5):1-38.
3. Roush SW, et al. Chapter 22: laboratory support for surveillance of vaccine-preventable diseases. In: Roush SW, et al, eds. Manual for the Surveillance of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention. Reviewed June 3, 2021. Accessed January 16, 2022. https://www.cdc.gov/vaccines/pubs/surv-manual/chpt22-lab-support.html
4. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 2013;62(18):362-365.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |