Platelet Antibody, Indirect (IgG), Flow Cytometry

Test Code

91805

CPT Codes
86022

Preferred Specimen

2 mL serum

Minimum Volume

1 mL

Instructions

Collect 5 mL whole blood in a serum separator tube (red-top), and separate serum before submitting.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis (Light, moderate and Gross) • Lipemia • Icterus • Any other anticoagulated tube (other than red top)

Methodology
Flow Cytometry (FC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Sat; Report available: 3-6 days

Reference Range

Negative

Clinical Significance

The identification of circulating platelet antibodies is useful in order to identify immune-mediated platelet destruction. Disorders associated with immune platelet destruction include isoimmune neonatal thrombocytopenia, drug induced thrombocytopenia, drug sensitivities, allergies and post transfusion purpura. The destruction is either autoimmune, where a malfunction in the immune response results in the production of antibodies directed against 'self' platelet specific antigens; or else platelet destruction occurs when the patient received platelet-specific antibodies from an outside source such as a non-compatible blood transfusion or maternal transfer across the placental barrier. In either of the above situations, the detection of platelet antibodies is useful in order to determine if an immune basis is responsible for the thrombocytopenia observed clinically.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.