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Integrated Screen, Part 2
Test Code16150
CPT Codes
81511*<br /> <strong>This test is not available for California patient testing.<br /> This test is for non-New York State clients only. For New York patient testing, use code 16977.</strong>
Includes
AFP, Unconjugated Estriol, hCG, Dimeric Inhibin A, PAPP-A (Pregnancy-associated Plasma Protein-A) from Maternal Serum Integrated Screen, Part 1; Interpretation
Preferred Specimen
3 mL serum
Minimum Volume
1 mL
Instructions
Perform between 14.0 weeks and 22.9 weeks gestational age.
A special Maternal Serum Screen requisition, designed to obtain patient data and the patient's informed consent, must be used when ordering this test, because these results are influenced by certain patient characteristics. All data requested on the requisition form must be completed. Maternal date of birth (MM/DD/YY), estimated date of delivery by US/LMP/PE, weight, race, insulin-dependent diabetes status, repeat sample (Y/N), number of fetuses, and neural tube defect history must be provided for interpretation of results.
A special Maternal Serum Screen requisition, designed to obtain patient data and the patient's informed consent, must be used when ordering this test, because these results are influenced by certain patient characteristics. All data requested on the requisition form must be completed. Maternal date of birth (MM/DD/YY), estimated date of delivery by US/LMP/PE, weight, race, insulin-dependent diabetes status, repeat sample (Y/N), number of fetuses, and neural tube defect history must be provided for interpretation of results.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 28 days
Refrigerated: 14 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia
Methodology
Chemiluminescence (CL) • Immunoassay (IA)
FDA Status
*PAPP-A Component only: This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.
Setup Schedule
Set up: Mon-Sat; Report available: 4-6 days
Limitations
Maternal age confirmation and number of fetuses may alter result interpretation. Maternal screening tests consistent with increased risk of trisomy should be confirmed with CVS or amniotic fluid specimen. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening.
Reference Range
See Laboratory Report
Clinical Significance
To assess maternal risk for carrying a fetus with Down Syndrome (Trisomy 21), Trisomy 18, or a neural tube defect. These types of tests are standard-of-care in obstetrics.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
