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InScape® PR, Quantitative, IHC with Interpretation

Test Code
70176


CPT Codes
88361

Preferred Specimen
Formalin-fixed paraffin embedded tissue submitted in IHC Specimen Transport Kit


Other Acceptable Specimens
3 unstained, positively charged slides


Instructions
Please include surgical pathology report

Note: Per ASCO/CAP guidelines, ER (Estrogen Receptor) and PR (Progesterone Receptor) positivity requires at least 1% of tumor cells to show positive nuclear staining of any intensity. A negative result for ER and PR will be reported if < 1% of tumor cells show staining.


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Do not freeze


Methodology
Immunohistochemistry (IHC)

Setup Schedule
Monday-Friday Morning
Report available: Next Day


Reference Range
See Medical Report


Clinical Significance
Breast cancer is a heterogeneous disease and there is a continual drive to identify markers that will aid in predicting prognosis and response to therapy. Estrogen receptor (ER) is probably the most powerful predictive marker in breast cancer management, both in determining prognosis and in predicting response to hormone therapies. Progesterone receptor (PR) is an estrogen-regulated gene and its expression is therefore thought to indicate a functioning ER pathway, although its value is less well established.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.