Aquaporin-4 Antibody (IgG), CBA

Test Code

93893

CPT Codes
86052

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.3 mL

Other Acceptable Specimens

0.5 mL CSF submitted in a sterile vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST®)

Methodology
Cell Binding Assay-Immunofluorescence Assay

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Wed, Fri; Report available: 8 days

Reference Range

Negative

Clinical Significance

Antibody to Aquaporin 4 causes neuromyelitis optica (NMO), a demyelinating disease of the central nervous system often confused diagnostically with multiple sclerosis (MS) and/or transverse myelitis. NMO causes optic neuritis and transverse myelitis. Early discrimination between MS and NMO is important, as optimum treatment for both diseases may differ considerably.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.