Estriol, Serum

Test Code

34883

CPT Codes
82677

Preferred Specimen

0.5 mL serum collected in a red-top tube (no-gel)

Minimum Volume

0.3 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum separator tube (SST)

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Sun-Fri; Report available: 3-5 days

Reference Range

Adult Males		≤0.18 ng/mL
Adult Females (non-pregnant)		≤0.21 ng/mL

Pregnancy
First Trimester		≤2.50 ng/mL
Second Trimester		≤9.60 ng/mL
Third Trimester		≤14.60 ng/mL

Clinical Significance

The placenta converts DHEA-S, produced by the fetal adrenals, to Estriol and other estrogens. Estriol is useful in assessing the fetal adrenals and placenta during pregnancy. More commonly, Estriol is one of the maternal serum biochemical markers used to screen for common chromosomal trisomies, especially Down syndrome.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.