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HIV-1 Genotype (RTI, PI, Integrase Inhibitors)
Test Code91692
CPT Codes
87900, 87901, 87906
Includes
HIV-1 Integrase Genotype
HIV-1 Genotype
HIV-1 Genotype
Preferred Specimen
4 mL plasma collected in an EDTA (lavender top) or PPT (white top) tube
Minimum Volume
1.2 mL
Other Acceptable Specimens
CSF collected in a sterile leak-proof container
Instructions
Do not freeze whole blood or any samples stored in primary tube. Freshly drawn specimens (whole blood) may be stored at 2-25°C for up to 24 hours prior to centrifugation. Separate plasma from cells within 24 hours of collection by centrifugation. If shipping frozen, transfer plasma to a leak-proof transport tube, then freeze prior to shipment. Follow manufacturer's instructions for collection tube handling.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 24 hours
Refrigerated: 6 days
Frozen: 42 days
Refrigerated: 6 days
Frozen: 42 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma received frozen in the plasma preparation tube (PPT) • Serum • Whole blood greater than 24 hours old • Frozen whole blood
Methodology
Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) • Sequencing
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 5-10 days
Reference Range
See Laboratory Report
Clinical Significance
Identify drug resistance mutations in HIV-1 patients failing antiretroviral regimens containing RT, PR or Integrase inhibitors.
Identify transmitted drug resistance mutations in the RT, PR or integrase genes in treatment-naive patients prior to initiation of antiretroviral therapy.
Identify transmitted drug resistance mutations in the RT, PR or integrase genes in treatment-naive patients prior to initiation of antiretroviral therapy.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |