IgG Synthesis Rate/Index, CSF

Test Code
7558


CPT Codes
82040, 82042, 82784 (x2)

Includes
Albumin (CSF and Serum)
IgG (CSF and Serum)
IgG Index, CSF
Synthesis Rate IgG, CSF


Preferred Specimen
2 mL CSF and 1 mL serum


Minimum Volume
1 mL CSF and 0.5 mL serum


Instructions
Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.

CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.

Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20°C and send frozen samples to the laboratory on dry ice.


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 90 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Xanthochromia; RBCs • Hemolysis in CSF


Methodology
Nephelometry

Setup Schedule
Set up: Mon-Sat; Report available: 2-5 days


Reference Range
See Laboratory Report


Clinical Significance
The IgG Synthesis Rate/Index is useful in diagnosing and monitoring patients with multiple sclerosis and other inflammatory diseases involving the brain and meninges.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.