A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Proteinase-3 Antibody
Test CodeCPT Codes
86021
Preferred Specimen
Minimum Volume
Transport Container
Transport Temperature
Specimen Stability
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Immunoassay (IA)
Setup Schedule
Reference Range
<1.0 AI | No antibody detected | |
≥1.0 AI | Antibody detected |
Clinical Significance
Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.
Goodpasture's Syndrome, first described by Ernest Goodpasture in 1919, is characterized today by the triad of diffuse lung hemorrhage, proliferative nephritis and the presence of anti-GBM autoantibodies, which are present as linear deposits along the glomerular and alveolar basement membranes, and as circulating antibodies.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |