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Serotonin Release Assay (SRA), Unfractionated Heparin
Test Code14627
CPT Codes
86022
Preferred Specimen
1 mL frozen serum
Minimum Volume
0.4 mL
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 6 months
Refrigerated: Unacceptable
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated
Methodology
Radiobinding Assay (RBA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Sun-Fri; Report available: 1-2 days
Reference Range
See Laboratory Report
Clinical Significance
Any patient with an unexplained fall in the platelet count of >40% during or after cessation of heparin therapy should be suspected of hit-heparin induced thrombocytopenia. This test is a functional assay of the PFU-antibody complex with heparin.
Note: Patients should not be on ticagrelor (Brilinta) as this may result in a false negative serotonin release assay.
Note: Patients should not be on ticagrelor (Brilinta) as this may result in a false negative serotonin release assay.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153