Copper, 24-Hour Urine

Test Code

365

Quest Code

365

CPT Codes
82525

Includes

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

7 mL aliquot of a well-mixed 24-hour urine collected in an acid-washed or metal-free container

Minimum Volume

3 mL

Instructions

Collect without preservative and transport in an acid-washed or metal-free plastic container. Record total volume on specimen container and on test requisition. To avoid contamination, do not measure 24-hour volume.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Random urine • Fecal contamination

Methodology
Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: Next day

Reference Range

15-60 mcg/24 h

Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Urinary copper concentrations are also useful to monitor patients on chealation therapy.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.