Paraneoplastic Antibody Evaluation with Reflex to Titer and Line Blot, Basic

Test Code
93876

CPT Codes
86255 (x10), 83519 (x5)

Includes
If Paraneoplastic Antibody Screen, IFA, Basic is positive for ANNA3, then ANNA-3 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255).
If Paraneoplastic Antibody Screen, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255 x4).
If Paraneoplastic Antibody Screen, IFA, Basic is positive or indeterminate, then Paraneoplastic Antibody, LB, Basic will be performed at an additional charge (CPT code(s) 84182 x5, 86341).
If Anti-Striated Muscle Antibody Screen is positive, then Anti-Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s) 86256).
If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 83519).


Preferred Specimen
6 mL frozen serum

Minimum Volume
3.5 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Frozen

Specimen Stability
Room temperature: 48 hours
Refrigerated: 48 hours
Frozen 21 days

Methodology
See individual tests

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Varies; Report available: 8-15 days

Reference Range
See Laboratory Report

Clinical Significance
Detection of antineuronal autoantibodies aids the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions. Identification of specific antineuronal autoantibodies may direct evaluation for underlying often occult malignancy. Characterization of autoantibody specificity may allow syndromic classification and assist in diagnosis and management. Antineuronal antibodies are detected and characterized based on indirect immunofluorescence staining pattern on multiple neuronal, non-neuronal tissues, and transformed substrate cells, and radioimmunoassays, and western blot analysis.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.