Liver Fibrosis, FibroTest-ActiTest Panel

Test Code
92688


CPT Codes
81596

Includes
Fibrosis Score, Fibrosis Stage, Fibrosis Interpretation
Necroinflammat Act Score, Necroinflammat Act Grade, Necroinflammat Interpretation
Alpha-2-Macroglobulin
Haptoglobin
Apolipoprotein A1
Total Bilirubin
GGT
ALT


Preferred Specimen
3.5 mL serum


Patient Preparation
Overnight fasting is preferred

Minimum Volume
2 mL


Instructions
Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection). Avoid freezing and thawing.


Transport Container
Plastic screw-cap vial


Transport Temperature
Frozen


Specimen Stability
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen -20° C: 5 days
Frozen -70° C: 28 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Patients <2 years old • QNS for one or more analytes


Methodology
Nephelometry • Spectrophotometry (SP)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat; Report available: 1-4 days


Reference Range
See Laboratory Report


Clinical Significance
FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis C (or B) individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of y-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.