Dengue Fever Antibody (IgM)

37580

1 mL serum

0.25 mL

Room temperature

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Avoid using hemolyzed, lipemic or bacterial contaminated sera

Set up: Sun, Tues, Thurs; Report available: 2-4 days

≤1.65

Interpretive Criteria

≤1.65	Antibody Not Detected
1.66-2.83	Equivocal
≥2.84	Antibody Detected

This assay detects IgM against all 4 Dengue virus serotypes, and the antibody response is not serotype-specific. A new IgM response may occur when exposure to a second dengue serotype occurs. In most patients, Dengue IgM is detectable after the sixth day following the onset of symptoms, and is highly suggestive of acute disease. Before day 6 of symptoms, both IgM and IgG may be negative and alternate testing (Dengue NS-1 Antigen or Dengue PCR) is recommended. A positive IgM may persist for several months after infection.
Cross-reactivity with other flaviviruses (eg. Zika virus) is known to occur; the extent and degree of serologic cross-reactivity varies. A positive Dengue virus IgM is presumptive evidence of infection. Patients at risk for Zika virus infection should also be evaluated for Zika virus per CDC guidelines.

Dengue hemorrhagic fever and Dengue shock syndrome are caused by infection of the RNA flavivirus transmitted by a mosquito vector. Paired acute and convalescent specimens that exhibit a significant change in titer are useful to confirm clinical diagnosis of infection.