Sensory-Motor Neuropathy Antibody Panel (Ganglioside)

Test Code

CPT Codes
83520 (x9)

Ganglioside GM-1 Antibodies (IgG, IgM), EIA
Ganglioside GD1a Antibody (IgG, IgM), EIA
Ganglioside GD1b Antibody (IgG, IgM), EIA
Ganglioside GQ1b Antibody (IgG), EIA
Ganglioside Asialo-GM-1 Antibody (IgG, IgM), EIA

Preferred Specimen
3 mL serum

Patient Preparation
Overnight fasting is preferred

Minimum Volume
1.6 mL

Transport Container
Transport tube

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature

Immunoassay (IA)

Setup Schedule
Set up and Report available: See individual assays

Reference Range
See Laboratory Report

Clinical Significance
The presence of antibodies to the gangliosides GM1, Asialo-GM1, GD1a and GD1b has been associated with motor and sensorimotor neuropathies. High titers of antibody to GM1 are most typical of multifocal motor neuropathy; however, antibodies to other gangliosides are often present. In most cases of chronic immune neuropathies, anti-ganglioside antibodies are IgM class. IgG antibodies have been reported less often, generally associated with acute conditions. Many reports have found increased anti-asialo-GM1 antibody titers in patients with multifocal motor neuropathy, lower motor neuron disease, sensorimotor neuropathy, or motor neuropathy with or without multifocal block, Guillain-Barré Syndrome, and amyotrophic lateral sclerosis. There may be a relationship between titers of asialo-GM1 antibodies and clinical status in individual patients. In some lower motor neuron disorders, improvement in strength has occurred after therapeutic reduction in anti-asialo-GM1 antibody titers. Polyclonal GQ1b IgG antibody can serve as an aid in the diagnosis of acute ataxia neuropathy with ophthalmoplegia or of Miller-Fisher Syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.