Perforin, IHC with Interpretation

Test Code
90356

CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block

Instructions
Please include surgical pathology report

Transport Container
IHC specimen transport kit

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen

Methodology
Immunohistochemistry

Setup Schedule
Set up: Mon-Sat a.m.; Report available: 2-3 days

Reference Range
Interpretive report

Clinical Significance
Perforin, a protein found within cytoplasmic granules, is a marker of cytotoxic lymphocytes. It is frequently positive, along with granzyme B, in extranodal natural killer (NK) cell lymphomas, aggressive NK cell leukemias and large granular lymphocyte (LGL) leukemias. Unlike TIA1, it is negative in hepatosplenic T-cell lymphoma.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.