Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G

Test Code
11368

CPT Codes
81400

Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume
3 mL

Other Acceptable Specimens
Whole blood collected in: sodium heparin (green-top), lithium heparin (green-top), or acid citrate dextrose ACD (yellow-top) tube

Instructions
Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship ambient immediately. Do not freeze.

Forward tissue and extracted DNA specimens immediately to the Molecular Genetics Laboratory; do not hold.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Methodology
Polymerase Chain Reaction and Detection

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Wed, Sat; Report available: 7-11 days

Reference Range
See Laboratory Report

Clinical Significance
Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction, and progression of atherosclerosis and also recurrent spontaneous abortion.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Hwy
San Juan Capistrano, CA 92675-2042



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.