Cystine, 24-Hour Urine [10947X]

Test Code
6016

CPT Codes
82131

Preferred Specimen
1.8 mL of a 24-hour urine collected in a 24-hour urine container

Minimum Volume
0.6 mL

Instructions
Do not use preservatives. Urine with a pH less than 2.0 will be rejected. Keep collection container refrigerated during 24-hour collection. Start collection after first morning void. Collect through first morning void of the next day. Take collection to the laboratory ASAP on the second day. The laboratory will mix sample well, measure total volume and remove an aliquot to send for testing. Freeze aliquot immediately.

Transport Temperature
Frozen

Specimen Stability
Room temperature: Unacceptable
Refrigerated: 48 hours
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
pH <2.0 • IVP within 48 hours of collection

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Tues, Thurs a.m.; Report available: 4-10 days

Reference Range
Pediatric  
  0-9 years 6-48 umol/24 hrs
  10-13 years 10-94umol/24 hrs
  14-17 years 17-102 umol/24 hrs
Adults 24-184 umol/24 hrs


Clinical Significance
Cystinuria is an autosomal recessive disease in which dibasic amino acids, including cystine, are excreted in excess. Cystine kidney stones account for approximately 1-3% of all kidney stones. Age of onset is often younger than with other types of kidney stones and the recurrence is approximately one-third.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.