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IgE Antibody (Anti-IgE IgG)
Test Code18877
CPT Codes
83520
Preferred Specimen
0.5 mL serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is preferred
Minimum Volume
0.3 mL
Instructions
Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate or gross hemolysis • Gross lipemia • Grossly icteric • Serum Separator Tube (SST®)
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon; Report available: 3 days
Reference Range
<168 ng/mL
Clinical Significance
Chronic urticaria is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with chronic urticaria, and anti-IgE antibody has been identified in another 5% to 10%. The anti-IgE assay will quantify autoantibodies to IgE which will aid in the diagnosis and management of autoimmune chronic urticaria.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
