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Cyclin D1 (BCL-1), IHC with Interpretation [15474X]
Test Code15474
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemical Assay (IHC)
Setup Schedule
Set up: Mon-Fri; Report available: 2 days
Reference Range
Interpretive report
Clinical Significance
Approximately 65% of mantle cell lymphomas (MCL) are characterized by a t (11; 14) (q13; Q32) gene translocation that causes deregulation of the expression of the BCL-1 gene. This abnormality in turn leads to deregulation of Cyclin D1. Detection of Cyclin D1 is useful in detecting disease.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153