Cutaneous Direct Immunofluorescence [18899X]

Test Code
18899

CPT Codes
88346, 88350 (x5)

Includes
IgG, IgA, IgM, C3, C5b-9, Fibrinogen

Preferred Specimen
Minimum: 4 mm skin biopsy submitted in Michel's fixative (supplied vial)

Instructions
Please provide site of biopsy.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 21 days
Refrigerated: 21 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Frozen samples

Methodology
Immunoassay (IA)

Setup Schedule
Set up: Mon-Fri a.m.; Report available: 3 days

Reference Range

See Laboratory Report



Clinical Significance
These studies contribute to the diagnosis of autoimmune blistering diseases, dermatitis herpetiformis, and IgA vasculitis. Important in the evaluation of other autoimmune and inflammatory skin diseases including non-IgA vasculitides and interface and lichenoid dermatitis/mucositis such as connective tissue disorders, lichen planus, etc. The panel includes the C5b-9 antibody to better distinguish between some forms of Lupus and Dermatomyocitis. Its presence or absence is also critical in the evaluation of other types of connective tissue diseases and many vasculitides.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.