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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Dengue Fever Antibody (IgG)
Test Code37579
CPT Codes
86790
Preferred Specimen
0.5 mL serum
Minimum Volume
0.1 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Icteric • Lipemia
Methodology
Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics Infectious Disease. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues-Sat; Report available: 2-4 days
Reference Range
<0.80
Interpretive Criteria
This assay detects IgG antibodies against all four Dengue virus types, and the antibody response to Dengue fever is not type specific.
The presence of IgG in the absence of IgM may Indicate either recent or past infection. Before day 6 of symptoms, both IgM and IgG may be negative, and alternate testing (Dengue NS-1 Antigen or Dengue PCR) is recommended. Cross-reactivity with other flaviviruses is known to occur; the extent and degree of serologic cross-reactivity varies.
Interpretive Criteria
| <0.80 | Negative |
| 0.80-1.09 | Equivocal |
| ≥1.10 | Positive |
The presence of IgG in the absence of IgM may Indicate either recent or past infection. Before day 6 of symptoms, both IgM and IgG may be negative, and alternate testing (Dengue NS-1 Antigen or Dengue PCR) is recommended. Cross-reactivity with other flaviviruses is known to occur; the extent and degree of serologic cross-reactivity varies.
Clinical Significance
Dengue and dengue hemorrhagic fever result from infection by any of four serotypes of dengue viruses. Transmission occurs through the bite of infected Aedes mosquitos. In most patients, Dengue Virus antibodies are detectable after the sixth day following the onset of symptoms. Strong cross-reactivity is seen with other group B arboviruses (flavivirus), including St. Louis encephalitis, Japanese B encephalitis, Rio Bravo, Powassan, and Yellow Fever viruses.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
