Histamine Release (Chronic Urticaria)

Test Code

CPT Codes

Preferred Specimen
1.5 mL serum collected in a red-top tube (no gel)

Patient Preparation
Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw

Minimum Volume
1 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature7 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross Lipemia • Icteric specimen • Specimen other than serum • Serum Separator Tube (SST®)

Cell Culture (CC) • Immunoassay (IA)

Setup Schedule
Set up: Tues, Thurs a.m.; Report available: 3 days

Reference Range
<16 %

Clinical Significance
Chronic Urticaria (CU) is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with CU, and anti IgE antibody has been identified in another 5%-10%.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.