|
|
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Histamine Release (Chronic Urticaria)
Test Code16838
CPT Codes
86343
Preferred Specimen
1.5 mL serum collected in a red-top tube (no gel)
Patient Preparation
Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw
Minimum Volume
1 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature7 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Icteric • Specimen other than serum • Serum separator tube (SST)
Methodology
Cell Culture (CC) • Immunoassay (IA)
Setup Schedule
Set up: Tues, Thurs a.m.; Report available: 3 days
Reference Range
<16 %
Clinical Significance
Chronic Urticaria (CU) is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with CU, and anti IgE antibody has been identified in another 5%-10%.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
