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Chromosome Analysis, Amniotic Fluid
Test Code14590
CPT Codes
88235, 88267, 88280
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
20 mL amniotic fluid collected in a sterile, screw-cap container, or nontoxic centrifuge tubes
Minimum Volume
5 mL
Instructions
30 mL is preferred if other testing, e.g., microarray, FISH, is ordered.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Note: Patient's age gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab). Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Note: Patient's age gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab). Signed informed consent is a requirement. Amniotic fluid kit and handling instruction available upon request.
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Culture • Karyotype • Microscopy
Setup Schedule
Set up: Mon-Sat; Report available: 9-12 days
Reference Range
Interpretive report
Clinical Significance
This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153